Decreased Intensity of Japanese Encephalitis Virus Infection in Chick Chorioallantoic Membrane Under Influence of Ultradiluted Belladonna Extract. American Journal of Infectious Diseases 6 (2): 24-28, 2010.The homeopathic remedy Belladonna is effective in preventing Japanese Encephalitis (JE), says a recent study conducted by the Department of Microbiology at the School of Tropical Medicine in Kolkata, the Department of Clinical and Experimental Pharmacology at the School of Tropical Medicine in Kolkata, the University of Health Sciences in Kolkata, the Department of Pathology and Microbiology in West Bengal, in collaboration with the the Drug Proving Research Centre of the Central Council for Research in Homeopathy (CCRH), and the Government of India in Kolkata, and the Department of AYUSH Ministry of Health in New Delhi.
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Abstract: Problem statement: No specific antiviral therapy is currently available despite an emergence and resurgence of Japanese encephalitis in South-East Asian Countries.Study conducted by: 1Bhaswati Bandyopadhyay, 2Satadal Das, 1Milan Sengupta, 3Chandan Saha, 4Kartick Chandra Das, 4Debabrata Sarkar and 5Chaturbhuj Nayak. 1Department of Microbiology, Virology Unit, School of Tropical Medicine, Kolkata-700073, India. 2Department of Pathology and Microbiology, D.N. De H. Medical College, West Bengal University of Health Sciences, Kolkata-700046, India. 3Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata-700073, India. 4Drug Proving Research Centre, CCRH, Government of India, Kolkata-700 046, India. 5Department of AYUSH, Ministry of Health, CCRH, Government of India, JLN Anudandhan Bhawan, 61-65 Intitutional Area, Janakpuri, New Delhi 110058.
There are only few recent studies, which were aimed to treat Japanese encephalitis with newer drugs. There is thus a real need for study on antiviral agents that can reduce the toll of death and neurological sequelae resulting from infection with this virus.
Approach: Optimum dilution of the JE virus was determined which could produce significant number of pocks on Chorioallantoic Membrane (CAM). Then ultradiluted Belladonna preparations were used to see their inhibitory action on JE virus infection in CAM.
Results: Ultradiluted Belladonna showed significantly decreased pock count in CAM in comparison to JE virus control.
Conclusion: Ultradiluted Belladonna could inhibit JE virus infection in CAM, which may be mediated through glycosidase inhibitory role of calystegines present in Belladonna.
Courtesy : Sue Young
